IxCell uses proprietary in vitro differentiation technology to differentiate IxCell™-iPSCs into highly purified human hepatocytes,ie,IxCell™-Hepatocytes, which may beused in new drug screening, hepatotoxicity testing and human disease research. IxCell™-Hepatocytes mimic human liver cells with good reproducibility, convenience, reliable source, and high purity (more than 80%). There is also no ethical issues involved, which differs IxCell™-Hepatocytes from traditional liver cells, such as directly isolated from animal or donated human liver tissues.
IxCell™-Hepatocytes presenttypical morphological features of hepatocytes and express hepatocyte-specific proteins such as ASGPR and albumin. IxCell™-Hepatocytes may be used as a closest in vitro model for the study of the pathogenesis of liver diseases, drug screening and drug toxicity studies.
Identification of IxCell™-Hepatocytes
lHepatotoxicity response modeling
lLiver endogenous metabolic pathway modeling
lHeterologous metabolic pathway modeling of liver
lLiver transport modeling
lHepatitis virus infection modeling